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GLP-1 agonists activate receptors in the brain's appetite centres, reducing hunger and increasing satiety, whilst also slowing gastric emptying to prolong fullness after meals, collectively leading to reduced food intake and weight loss
It is important to recognise that patients prescribed GLP-1 agonists often have underlying conditionssuch as type 2 diabetes, obesity, hypertension, and dyslipidaemiathat independently increase cardiovascular and thrombotic risk
For patients using peptide therapy, we typically retest after 46 weeks to monitor response and adjust treatment if needed
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