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10.1016/S0140-6736(18)32261-X 33 HolmanR

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For two key concepts, comprehensive search strings were created using a combination of free-text keywords and controlled vocabulary (MeSH/Emtree terms): (1) GLP-1 receptor agonists (including specific drug names) and (2) inflammatory biomarkers (C-reactive protein, interleukin-6, and tumor necrosis factor-alpha)

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What to Expect in Your First Week on GLP-1 During the initial days of GLP-1 therapy, most patients notice relatively subtle changes, as the medication requires time to reach therapeutic levels and exert its full effects

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and pheomelanosomes are spherical, characterized by granular deposition of the melanin [4]

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