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Description

Gastrointestinal effects represent the most common concern

Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells

The approach begins with a detailed history of concussion, blast exposure, repetitive head impacts, behavioral change, medication use and endocrine symptoms