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Rab7 overexpression in mice was associated with increased autophagic activity [75], a mechanism proposed to lower cholesterol in NPC mutant cells [10, 76] that is possibly normalized in drug-treated NPC1 mutant cells in this study, as judged by the reduced amounts of autophagy markers
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Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics
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