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The findings of the study also demonstrated that the majority of patients (97.5%) exposed to GLP-1 RAs used semaglutide, while the remaining 2.5% of patients used lixisenatide
The authors of the study identified two well-known side effects of semaglutide that likely led to DKA: appetite suppression and nausea
(6) Rapid tachyphylaxis: Continued tyramine exposure depletes releasable NE stores and replaces NE with pharmacologically weak false neurotransmitter stores, leading to diminished responsiveness despite ongoing tyramine presence
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