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Appropriate diabetes treatment which may include semaglutide can help prevent long-term health problems like heart disease, kidney disease, and vision problems

Unlike earlier GLP-1 receptor agonists like semaglutide (Ozempic/Wegovy) that target a single hormone pathway, or tirzepatide (Mounjaro/Zepbound) that targets two, retatrutide activates three distinct metabolic receptors : GIP, GLP-1, and glucagon

It is important to understand whether the cardiovascular benefits of GLP-1RAs are limited to those who also experience glycemic and/or weight benefits, or we see benefits in hard outcomes more broadly