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Currently, no published clinical trials have specifically examined tirzepatide's effects on cognitive function or Alzheimer's disease progression in humans

Key Takeaways Starting dose: 2.5 mg once weekly for 4 weeks (sub-therapeutic, intended for tolerability) Titration pace: Increase every 4 weeks: 2.5 5 7.5 10 12.5 15 mg Maintenance options: 5, 10, or 15 mg

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While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD