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A 30-year-old likely has far fewer senescent cells than a 60-year-old, which means: Younger individuals may notice less from FOXO4-DRI simply because there are fewer target cells to clear Older individuals or those with conditions associated with accelerated senescence (chronic inflammation, metabolic syndrome, prior chemotherapy) may have more to gain and more pronounced initial side effects from a larger clearance event Overall Health and Immune Function The immune system must clear apoptotic cells after FOXO4-DRI triggers their death

Regular injections ensure that levels remain stable, whereas infrequent injections may result in declining B12 levels over time

In: GlickMGreenbergMSLockhartPBChallacombeSJ, editors

For individuals who are sensitive to needles, this might also help minimize the pain levels you are going to experience when injecting the needle