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GSSG is widely believed to be involved in the oxidation of PDI, but it has been shown that the ER flavoprotein Ero1 catalyses the oxidation of PDI in vivo and in vitro (Frand & Kaiser, 1998, 1999
While there is a theoretical benefit to combining these two metabolic powerhouses, the practical risks of low blood sugar and severe digestive distress are significant
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People with sensitive digestive systems should start with low doses or avoid berberine-containing products entirely
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