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Factors That Affect the Duration of Tiredness Dose escalation speed, nutritional adequacy, hydration status, pre-existing conditions such as anaemia or hypothyroidism, and sleep quality all influence how long retatrutide-related fatigue persists

Stick to a weekly schedule for Semaglutide: Take Semaglutide on the same day and at the same time each week

Expected fatigue feels like needing one extra coffee in the morning or slightly lower motivation for exercise, but you can still function normally