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The Lancet: Diabetes & Endocrinology

GLP-1s glucagonostatic effect is retained in Glp1r / islets We tested the effects of genetic ablation of Glp1r (encoding GLP-1 receptor [GLP-1R]) on insulin and glucagon secretion

[sources 15] Upon activation by amphetamine, TAAR1 can couple to the G s alpha subunit and increase intracellular cAMP production via adenylyl cyclase activation, which triggers PKA- and PKC-mediated transporter phosphorylation