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4) Potency: Stronger drug potency effectively reduces the minimum concentration needed to achieve desired efficacy which allows for longer dosing interval assuming all else equal

To further confirm the implication of reduced GRK2 levels particularly in the pancreas in the observed phenotype, and to avoid the possible influence of reduced GRK2 in other tissues, Exendin-4-mediated stimulation of insulin secretion was measured in pancreatic islets isolated from WT or GRK2+/ mice