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3B), along with a slightly increased expression of AHCY (Fig

These studies reported preventive impacts of polyphenols in brain oxidative stress of AD mice after the administration of different polyphenols, such as GA (100 mg/kg, p.o., for 112 days), CGA (80 mg/kg, p.o., for 16 weeks), which increase the level of glutathione peroxidase, superoxide dismutase, and catalase as three antioxidative stress enzymes in the brain of in the high-fat diet (HFD)-fed rat and transgenic mice respectively [20, 23], and resveratrol (60 mg/kg, p.o., for 24 weeks) in obesity-related AD mice at the age of 6-weeks-old [34]

A longer half-life helps the drug do its job between doses

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