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2.5.2 Test material exposure To prepare the stock solutions to perform the test material exposures, buffered saline solution (0.9% NaCl, 10 mM HEPES, 1.25 mM CaCl 2 ), DMSO or culture medium (Table 1)

Beyond cancer biology, DES(1-3) IGF-1 has been investigated in neuroprotection models, where its high potency and reduced IGFBP binding facilitate clean receptor activation in brain tissue preparations where IGFBP concentrations would otherwise limit native IGF-1 activity

It also promotes skin health by lightening the skin tone and reducing dark spots, melasma, and hyperpigmentation

doi: 10.1016/j.pmpp.2020.101513 72 SkopelitouK.MuletaA