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R The key catalytic mechanism involves lowering the pKa of the glutathione thiol from 9.0 to approximately 6.5, generating the thiolate anion (GS) at physiological pH, which is a potent nucleophile
It is primarily studied for its role in skin repair, tissue regeneration, and aging research
Beyond sleep, DSIP has been studied for post-stroke motor recovery (Tukhovskaya et al., Molecules 2021), modulation of oxidative stress, regulation of corticotropin (ACTH) and anticonvulsant properties
Clifford, S
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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