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Johnson WD, Kroon JJ, Greenway FL et al
Patients typically begin noticing that they feel hungrier between meals, that portions that previously satisfied them no longer feel filling, and that food cravings particularly for higher-calorie foods begin to increase
[57] In individuals with obesity, chronic low-grade inflammation often leads to "leptin resistance"a pathological state where circulating leptin levels are high, but the brain fails to register the signal, leading to persistent hunger
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