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9.7.3 Oxidative stress mitigation and lipid profile optimization Chronic hyperglycemia in diabetes induces mitochondrial dysfunction and excessive ROS production
3 Compared directly with liraglutide (Saxenda), semaglutide performed significantly better
In the STEP 1 trial, patients receiving semaglutide 2.4 mg with lifestyle support lost an average of 14.9% of their starting body weight over 68 weeks
Current recommendations from the American Society for Metabolic and Bariatric Surgery and the Endocrine Society support considering these agents as part of comprehensive management when lifestyle modifications prove insufficient and specific clinical criteria are met
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