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Nuclear localization of Pdha1 enhances binding between P300 and the pluripotency core regulators SRY-box transcription factor 2 (Sox2)/ Krppel-like factor 4 (Klf4)/ octamer-binding transcription factor 4 (Oct4) at transcriptional start sites and enhancer regions of pluripotency genes by elevating the levels of H3K9ac and H3K27ac modifications, thus facilitating the establishment of the pluripotency gene network(Li 2022)
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