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Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms
Proc Natl Acad Sci 94(14):75317536 Hussain F, Kayani HU (2020) Aging-Oxidative stress, antioxidants and computational modeling
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