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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

Side effects such as nausea, reflux, cramping, and constipation are common side effects that may limit use, too

The glowing safety claims no toxic effect no side effect in trials come almost exclusively from the peptides original proponents

Systemic Strategies Individual clinical encounters require complementary systemic responses