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Tirzepatide differs from GLP-1RAs in that, in addition to agonizing the GLP-1R, this drug also acts as a GIPR agonist, providing direct effects on white adipose tissue that may further benefit MASH histology beyond glycemic control and weight loss [52]
Studies have shown that high doses of PPR (e.g., 10 mg/kg) significantly reduce sperm motility, concentration, and viability in adult male rats, with adverse effects on key reproductive markers and antioxidant enzymes (70, 71)
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Semaglutide helps many people lose weight by reducing appetite and helping them feel full faster
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