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Microneedlings purely mechanical action does not interact with skin pigment, making it the safer and often preferred option for Fitzpatrick Types IIIV
Its molecular weight is approximately 340 Da for the tripeptide and 404 Da as the copper complex, placing it near but not comfortably below the 500 Da theoretical threshold for efficient transdermal permeation
Many run warmer than a standard refrigerator
The time line of experimental procedure was shown at Fig 1
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