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One of the most important roles of glutathione is its involvement in a post-translational modification (PTM) process called glutathionylation

The concerted efforts of synthetic chemists over the years have led to a common understating that organo-selenium compounds depending on their chemical structure can mimic GPx-like activity [71,72,73]

Additionally, the depletion of MnSOD (superoxide dismutase) in RPE cells triggered the Hsp70-linked ubiquitin-dependent cleavage of GPX4, exacerbating ferroptosis of these cells (89)

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