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People with substance use disorder keep using drugs or alcohol even though it causes problems in their life

Each component enhances the others GH optimization improves tissue perfusion that enhances NAD+ delivery, while NAD+ fuels the sirtuin pathways that regulate how effectively cells respond to GH and metabolic signals

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Further, since this was an investigation focused a priori on S-5-HT levels, it remains unknown if the effects were specific to serotonin synthesis, or if other pathways were also affected