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The pattern is consistent: strong mechanistic plausibility from preclinical data and adjacent human safety, no direct human efficacy or long-term safety data on IGF-1 LR3 itself

Knop FK, Aroda VR, do Vale RD, et al

The Big Picture GLP-1 drugs may represent a paradigm shift : From treating isolated diseases To targeting shared biological systems (brain + metabolism + inflammation) But heres the tension: Mass adoption is outpacing science Medicine is playing catch-up Experts are clear: We are at the beginning, not the end , of understanding these drugs.

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