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Some users describe this as a leaning effect, though its important to frame this carefully: IGF-1 LR3 isnt a stand-alone weight loss solution, but rather a potential support tool for body composition when combined with lifestyle changes
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These prespecified analyses considered factors such as age, hypertension, heart failure, eGFR, proteinuria, new users after the index day, enrollee after 2006 and concurrent usage of other medications for glycemic control, and renin-angiotensin-aldosterone system (RAAS) blockers
No retatrutide withdrawal trial has measured that effect, so the estimate comes from the other two drugs
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