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It's subtle
J Nutr 115:399410 Zapara TA, Simonova OG, Zharkikh AA et al (2004) Seasonal differences and protection by creatine or arginine pretreatment in ischemia of mammalian and molluscan neurons in vitro
A mild shortage might simply require dietary tweaks, whereas severe depletion necessitates immediate, potent B12 injections
it should be clear and colorless, and you should discard it immediately if you notice cloudiness, discoloration, or particles floating in the vial
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