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Some of those possible causes include, but arent limited to, certain medications, stress, poor nutrition, adrenal disorders, genetic or chromosomal problems, structural issues with the uterus or vagina, pituitary disorders or tumors, PCOS, ovarian tumors, kidney disease, chronic illness, radiation therapy, chemotherapy, and issues with the hypothalamus.25 26 You should only consider a supplement for amenorrhea symptom management after the underlying cause is determined and your doctor confirms its safe for you to take one