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Studies of FDA-approved tirzepatide showed average weight reductions of approximately 2021% in study populations
The pattern aligns with the slope rather than the cliff model
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Consider: Escalating to next dose tier Evaluating adherence and lifestyle factors Checking for medication-interfering conditions (hypothyroidism, PCOS, sleep apnea) Discussing alternative treatments Dose-response comparison table: Wegovy vs Zepbound Data from STEP 1 (Wilding et al., NEJM 2021) and SURMOUNT-1 (Jastreboff et al., NEJM 2022)
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