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Following the positive REDEFINE 1 Phase 3 data (published June 2025, PMID: 40544433), Novo Nordisk announced plans to file regulatory applications for CagriSema for obesity in the United States (FDA), European Union (EMA), and other major markets in 20252026
But the risk isnt clear-cut and, in most cases, its related to high homocysteine levels
Engages dopaminergic and serotonergic systems in rodent CNS injury models
In fact, some observational studies suggest slightly lower fracture risk at high B12 blood levels
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