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Spinocerebellar ataxia type 1 (SCA1) endoplasmic reticulum (ER), (as seen with neuroserpin mutations that cause familial encephalopathy with neuroserpin inclusion bodies) extracellularly excreted proteins, amyloid-beta in Alzheimer's disease There are two main avenues eukaryotic cells use to remove troublesome proteins or organelles: ubiquitinproteasome: protein ubiquitin along with enzymes is key for the degradation of many proteins that cause proteopathies including polyQ expansions and alpha-synucleins
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Scurvy in the Modern World: Extinct or Not?. Cureus vol
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