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Findings reported in the New England Journal of Medicine and through Eli Lillys international research programme confirm its potential as a strong oral alternative to injectable GLP-1 therapies
This positive effect on UPS activity helps combat the accumulation of damaged proteins, a hallmark of aging
However, NICE guidance (NG28) recommends self-monitoring when GLP-1 agonists are combined with insulin or sulfonylureas, which increase hypoglycaemia risk
Many people require ongoing medication to maintain weight loss, as research shows significant weight regain when semaglutide is discontinued
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