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The participants had an average age of 56, a mean BMI measurement of 38, and a mean HbA1c blood sugar level of slightly more than 8

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Endocrinology (2004) 145(6):26539.10.1210/en.2004-0015 53 Sasaki-HamadaSNakamuraRNakaoYAkimotoTSanaiENagaiMet alAntidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice