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[2] For subclinical hypothyroidism (elevated TSH with normal free T4), treatment should be considered if TSH 10 mIU/L on two tests 3 months apart, or as a time-limited trial in symptomatic adults, especially if TPO-antibody positive
Severe deficiency can contribute to fatty liver changes, which is one reason choline gets framed as liver support. Details are summarized in the NIH ODS Choline fact sheet for health professionals
Neelakantan, H., et al
Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions in diet-induced obese mice
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