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High IV dosage or high local concentrations of methylene blue may cause formation of methemoglobin and cyanosis
A 2018 review by Sikiric described its effects on the VEGF pathway, which drives the formation of new blood vessels (angiogenesis), and on the nitric oxide system, which regulates blood flow and inflammation
Dose: 3 capsules once daily with a meal (more sensitive people may need to start at 1 capsule and work up)
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