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Immunity (2012) 36:12031

Raghu G, et al

It also plays a critical role in the bodys defense system against oxidative stress by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E

Together, these changes mean that a much higher fraction of administered IGF-1 LR3 reaches tissue receptors as free ligand compared to an equivalent molar dose of native IGF-1