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Animal acute toxicity studies across Sikiric's group publications have consistently shown a low acute toxicity profile, with no defined lethal dose identified in standard rodent models
Skopelitou et al., 2012a,b)
However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH
While the liver produces some choline, it's not always in sufficient amounts
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