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For instance, due to their much smaller polar headgroup relative to their fatty acid chains, PE lipids have a negative spontaneous curvature and thus they self-assemble into non-bilayer structurestypically resulting in hexagonal phases unless paired with other lipids or sterols
In the TME, cancer cells can transfer dysfunctional mitochondria carrying mutant mtDNA into T cells, and these imported mitochondria persist rather than being efficiently cleared, driving metabolic disruption and functional decline that favors immune escape (138)
this may be because NMN first requires dephosphorylation into NR before uptake into cells 39
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