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In a CVOT of an osmotic mini-pump delivering exenatide subcutaneously (ITCA 650) over 36 months, ITCA 650 had a neutral effect on MACE compared with placebo over 16 months [248]
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Lastly as the majority of GLP-1 RAs in this study were semaglutide, this may not apply to all GLP-1 RAs and additionally, because the analysis excluded over 26,000 patients who could not be matched, the results may not apply to the full spectrum of patients taking these drugs in the real world, particularly those with more complex health profiles. MNT spoke with David I
Synbiotic works on the infrastructure side the microbiome, the gut barrier, digestive enzyme support, and the prebiotic environment that L-cells depend on
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