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Z., Vernooy, S
Importantly, regulations make no carve-outs for AI: if an AI-derived model or document is part of manufacturing, it is subject to the same validation, documentation, and review requirements as any other system
However: Longer-term safety data (5+ years) is still being collected Individual risk factors vary significantly Regular medical monitoring essential for ongoing safety assessment Some individuals develop side effects requiring discontinuation Long-term cardiovascular benefits observed in some trials (SELECT trial with semaglutide) Healthcare providers should regularly reassess whether continued treatment remains appropriate for individual circumstances based on ongoing benefits, risks, and patient preferences
As the results, ferroptosis was identified as a core facilitator of renal interstitial fibrosis in TECs during UUO
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