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Glucagon-like peptide-1 (GLP-1) receptor agonists are a family of antihyperglycemic drugs that have demonstrated potent HbA1c reduction, low risk of hypoglycemia, with associated weight reduction, and proven cardiovascular and renal benefits.24 In this review we describe this type of drugs, their cardiovascular and renal benefits, as well as their clinical potential in patients with DKD, especially with the new oral semaglutide formulation, now available on the market

The GLP-1 pathway GLP-1 is secreted primarily by endocrine cells in the small intestine and proximal colon in response to nutrient ingestion

First the mitochondrial ATP is measured

Compared to bariatric surgery, semaglutide offers similar weight loss results for many people without surgical risks, recovery time, or permanent anatomical changes