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These are usually short-lived and manageable

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We also extracted data on drugs known to affect urine stone risk profile if patients were on them during baseline and follow-up 24-hour urine collection: allopurinol, sodium bicarbonate, potassium citrate, thiazide and thiazide-like diuretics (indapamide, hydrochlorothiazide, chlorthalidone), and sodium-glucose cotransporter-2 inhibitors

The intended effect, she said, is to push companies toward submitting their single strongest, most competitive idea per topic rather than hedging across multiple submissions