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These experiments demonstrated that the relatively low dose of MK-801, required for achieving a synergistic weight loss by the conjugate, does not affect the body temperature after 14 days of repeated dosing, as none of the treatment groups displayed different core temperature compared with the vehicle-treated mice (Extended Data Fig
doi: 10.2337/dc19-0883 12 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al
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10.4158/CS-2017-0153 118
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