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Under hyperglycemic conditions, SGLT2-dependent SGK1 activation drives canonical tubular epithelial cell pyroptosis, as confirmed by GSDMD-mediated pore formation and the release of IL-1, IL-18, and LDH (167)
Clinical utility of cardiovascular risk scores for identification of people with type 2 diabetes more likely to benefit from either GLP-1 receptor agonist or SGLT2 inhibitor therapy
Experts, however, caution that maintaining weight loss is heavily reliant on continued use of the drug
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