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Higher NNMT activity means more nicotinamide gets shunted away from NAD+ production

This can happen as the result of a problem known as functional vitamin B12 deficiency, where there's a problem with the proteins that help transport vitamin B12 between cells

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The combination of reduced caloric intake (from tirzepatide appetite suppression) and enhanced fat breakdown (from AOD 9604 lipolysis) creates a steeper downward trajectory