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Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al
If diarrhoea is accompanied by fever, blood in stools, severe abdominal pain, or dehydration, an infectious or inflammatory cause should be considered and medical attention sought promptly
Once the deficiency is addressed, a maintenance dose can be given to keep B12 levels within the optimal range
B12 helps divide the process and the amino acid known as homocysteine, which when levels are elevated can contribute to things such as stroke
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