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The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance
These are often listed as U-100 insulin syringes with an attached needle
Suitable for dissolving many research peptides and compounds
My honest opinion: the signal is strong enough to warrant formal study, and it's frustrating that the economics of peptide research make that unlikely anytime soon
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