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Elastin crosslinks with collagen under the action of lipoxygenase (LOX), further hardening the ECM structure, which ultimately contributes to metastasis and ensures tumor cell resistance to treatment [165]
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Absorption falls substantially and the month looks like non-response
PLoS Comput Biol 11:e1004401 Demidenko E, Miller TW (2019) Statistical determination of synergy based on Bliss definition of drugs independence
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