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DHAR catalyses the reduction of DHA to AsA using glutathione (GSH) as a hydrogen donor before the spontaneous hydrolysis of DHA to irreversibly form 2,3-diketogulonic acid
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Shedding reductions of 25-30% are commonly reported
It was added to the Prohibited List in 2022 as a non-approved substance, reflecting its transition from an obscure research compound to a significant "substance of interest" in professional athletics
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