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Thiamine (B1) is involved in many body functions, including nervous system and muscle function, the flow of electrolytes in and out of nerve and muscle cells, digestion, and carbohydrate metabolism

On the other hand, the adverse events of GLP-1 drugs have been extensively characterized from large randomized trials with placebo controls and, in the United States, from reports derived from 12% of Americans who are currently taking these drugs

There are more nerves in the muscle in the thigh than in the deltoid muscle, and it is easier to find the safe place to do the injection in the upper arm (which is why this is a common used place to give vaccinations i.m.)

Applying that standard to AOD-9604 in adolescents requires acknowledging that the evidence base consists of a single rodent study as its primary source